Gregmal Posted February 1, 2019 Share Posted February 1, 2019 AKA CRISPR I haven't seen anything here on this so I thought I'd do everyone the favor of floating what is described by scientists as a "once in a generation breakthrough". Yes I know this idea is not for everyone, but thats OK, it can only be for those that want to make money or have the ability to see where the puck is going...If you require a single digit PE and low P/B in order to make an investment you can stop reading now. If you are open minded and wish to continue, I introduce you to the breakthrough technology... That is CRISPR and the variants Cas9/12/cpf1/3. What CRISPR does is effectively target specific genes within an organism by activating proteins naturally occurring within the immune system and directing via RNA an attack on a specified areas. In layman's terms think of going to the dermatologist and having a mole removed. CRISPR more or less removes a malignant mole from your genome. It is that simple and this is why it is going to change modern medicine. Up until now, the majority of treatments for any sort of ailment involved putting together a concoction of, lets call them, "things" and then seeing how they reacted with the body. CRISPR entirely removes this aspect of risk. It is as simple taking a taking a scissor to an undesired or harmful trait. A good piece is found here, https://www.technologyreview.com/s/604126/edible-crispr-could-replace-antibiotics/ So far, CRISPR has been effective on every complex organism it has been attempted on. It is able to target just about any disease, and on a scientific level, is so easy to apply high school students are messing around with it in AP classes. CRISPR itself is not really that controversial, however the aspect that is controversial stems from the optionality. When programming the RNA so to speak, you have two options. One is to cut out the genome, and the other is to cut out and replace. Cutting out and replacing is where you can take an undesired aspect and flip it into a desirable one. There is a fortune that will be made from this and there are a bunch of different avenues where one can look to invest. Rather than follow specific companies I have found it helpful to follow specific doctors whom have developed and patented this "technology". These names are Jennifer Doudna, Feng Zhang, Emmanuelle Charpentier and George Church. The various fundraising rounds have been loaded with the biggest names out there. Bill Gates specifically has described this as "one of the most powerful technologies of the 21st century". There are a handful of public companies with holds on the patents, as well as a good few private companies with shares occasionally available which offer an opportunity to play this space. The names I think are worth following are Caribou Biosciences, Editas Medicine, Crispr Therapeutics, Synthego, and Beam Therapeutics. I have found Nature.com, Pubmed, and Researchgate to be sites with ample resources on this and database access to current events. Curious if others have studied this, and/or made investments or have ways to play this. Be forewarned that yes, these companies will not likely to make money for years and that yes, this whole theme is not even in the first inning yet; it's just batting practice, maybe pregame warm ups. But the opportunity is so massive and the patents even today IMO are severely undervalued mainly because people fail to fully understand or appreciate the potential and have all sorts of misnomers floating around because of stigmas attached to boogeyman words and phrases like "GMO" and "playing god". Link to comment Share on other sites More sharing options...
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