Coronavirus

[ERICOPOLY]

More fuckups with the data.

 

https://www.theatlantic.com/health/archive/2020/05/cdc-and-states-are-misreporting-covid-19-test-data-pennsylvania-georgia-texas/611935/

 

If China made that mistake it would be a conspiracy and nations would demand that the WHO investigate.  We just get "China is lying" and we don't hear the more human causes for these scandals.

[Peregrine]

On another note, it's interesting how Japan has had 6 COVID-related deaths per 1 mm capita (near the lowest in the world) despite not having a lockdown and having one of the oldest populations in the world and some of the densest cities in the world. I'm guessing that simply hand washing and wearing a mask in public places does 90% of the work in reducing transmissions?

Yes. Now can all you have to is turn Americans into Japanese. Hygiene obsessed, mask wearing little drones, social distance, no kissy huggy stuff. Good luck.

 

This is who you get to work with.

 

 

That's fair, though I suspect that mask adherence in the denser populated blue states will be a lot higher which can help mitigate the spread more in these places where transmission rates are a lot higher.

[Liberty]

https://www.researchsquare.com/article/rs-27223/v1

 

"Hydroxychloroquine in the treatment and prophylaxis of SARS-CoV-2 infection in non-human primates"

[Spekulatius]

https://www.researchsquare.com/article/rs-27223/v1

 

"Hydroxychloroquine in the treatment and prophylaxis of SARS-CoV-2 infection in non-human primates"

 

Sounds like Trump considers himself eligible for the study and participates voluntary.

[Jurgis]

https://www.researchsquare.com/article/rs-27223/v1

 

"Hydroxychloroquine in the treatment and prophylaxis of SARS-CoV-2 infection in non-human primates"

 

Look who wrote this:

 

Pauline Maisonnasse, Jérémie Guedj, Vanessa Contreras, Sylvie Behillil, Caroline Solas, Romain Marlin, Thibaut Naninck, Andres Pizzorno, Julien Lemaitre, Antonio Gonçalves, Nidhal Kahlaoui, Olivier Terrier, Raphael Ho Tsong Fan, Vincent Enouf, Nathalie Dereuddre- Bosquet, Angela Brisebarre, Franck Toure, Catherine Chapon, Bruno Hoen, Bruno Lina, Manuel Rosa Calatrava, Sylvie van der Werf, Xavier de Lamballerie, Roger Le Grand

 

Any true red blooded Americans in this list?

 

Clearly fake news from illegal immigrant liberals.

[Spekulatius]

Hasn’t gotten. Ich attention, but the Uk COVID-19 score card is now worse than Italy’s. Same death/pop number and since the UK is still adding new cases much more so than Italy, they are sure to overtake them.

# Country death/1M population.

5 UK 542

6 Italy 542

 

[Read the Footnotes]

https://www.researchsquare.com/article/rs-27223/v1

 

"Hydroxychloroquine in the treatment and prophylaxis of SARS-CoV-2 infection in non-human primates"

 

Sounds like Trump considers himself eligible for the study and participates voluntary.

Trump probably isn't even really taking Hydroxychloroquine.

 

He and others in the chain of command and military have probably been secretly receiving prophylactic treatments of plasma for months.

 

It's a great explanation for why he has been his normal self and has shown no signs of his supposedly legendary Germaphobia.

 

If you've forgotten, supposedly he couldn't have stumpfed the Russian prostitutes at the pee palace because he's so Germaphobic it would have been out of character. I'm left to conclude that either there are pee tapes out there or he's been getting convalescent plasma for months.

 

This is also a good explanation for why we did those repatriation flights to military bases and got people to volunteer for military-led "research". Also, not a bad explanation why we allowed for cruise ships to become Petri dishes. You've got to get the plasma from somewhere and you probably want to get it early and from a verifiable source. Importation from Wuhan is a great technique for that.

[rb]

Nah, he probably thinks he's taking HQC but they're really giving him kids vitamins or something.

[Read the Footnotes]

Nah, he probably thinks he's taking HQC but they're really giving him kids vitamins or something.

That's actually reassuring. After posting on a public forum that Trump is secretly getting an effective prophylactic treatment that is not available to the rest of us I closed my curtains, turned off the lights and started waiting for the CIA/NSA/Deep State blacked out vans to park in front of my house. Or in the case of the Trump administration I guess I should be worried about getting a visit from a mob lawyer from Queens.

[ERICOPOLY]

Nah, he probably thinks he's taking HQC but they're really giving him kids vitamins or something.

That's actually reassuring. After posting on a public forum that Trump is secretly getting an effective prophylactic treatment that is not available to the rest of us I closed my curtains, turned off the lights and started waiting for the CIA/NSA/Deep State blacked out vans to park in front of my house. Or in the case of the Trump administration I guess I should be worried about getting a visit from a mob lawyer from Queens.

 

He's probably being given Truvada under the PReP program given his exposure to Russian prostitutes and porn-stars with the accompanying high HIV risk.

[DooDiligence]

Fun fact: Trumps grandfather died of the flu in 1918.

[Liberty]

[Investor20]

https://www.researchsquare.com/article/rs-27223/v1

 

"Hydroxychloroquine in the treatment and prophylaxis of SARS-CoV-2 infection in non-human primates"

 

Sounds like Trump considers himself eligible for the study and participates voluntary.

Trump probably isn't even really taking Hydroxychloroquine.

 

He and others in the chain of command and military have probably been secretly receiving prophylactic treatments of plasma for months.

 

It's a great explanation for why he has been his normal self and has shown no signs of his supposedly legendary Germaphobia.

 

If you've forgotten, supposedly he couldn't have stumpfed the Russian prostitutes at the pee palace because he's so Germaphobic it would have been out of character. I'm left to conclude that either there are pee tapes out there or he's been getting convalescent plasma for months.

 

This is also a good explanation for why we did those repatriation flights to military bases and got people to volunteer for military-led "research". Also, not a bad explanation why we allowed for cruise ships to become Petri dishes. You've got to get the plasma from somewhere and you probably want to get it early and from a verifiable source. Importation from Wuhan is a great technique for that.

 

If anything the HCQ (Optionally with Zinc) will work earlier its given.

 

Viruses are not living things.  So they cannot be killed.  Read about late diagnosis HIV.

 

So we can only stop replication of viruses - hence if they work, they should work better earlier they are given.

 

https://www.ny1.com/nyc/all-boroughs/news/2020/05/12/nyu-study-looks-at-hydroxychloroquine-zinc-azithromycin-combo-on-decreasing-covid-19-deaths

 

NEW YORK - Researchers at NYU's Grossman School of Medicine found patients given the antimalarial drug hydroxychloroquine along with zinc sulphate and the antibiotic azithromycin were 44 percent less likely to die from the coronavirus.

 

Trump took HCQ+Zinc.  In above study they said it did not work in ICU but worked before ICU.  That is it worked before the virus multiplied in the body extensively.

 

So, one would expect it to work at the earliest stage - prophylactic.  Trump had come in contact with Covid positives.  So, his doctors gave him the medicine.  It is a prescription medicine.

 

The Indian govt has recently expanded its use

https://www.msn.com/en-in/news/other/govt-expands-hydroxychloroquine-as-prophylactic-for-asymptomatic-health-workers-fighting-covid-19/ar-BB14u2ZN

Govt expands Hydroxychloroquine as prophylactic for asymptomatic health workers fighting COVID-19

 

https://theprint.in/health/hcq-breakthrough-icmr-finds-its-effective-in-preventing-coronavirus-expands-its-use/427583/

HCQ breakthrough: ICMR finds it’s effective in preventing coronavirus, expands its use

 

They are reporting further clinical studies of this prophylactic use and results are expected in July.

 

S. Korea also they used it as prophylactic and even though its not a randomized double blind study, again there were encouraging results

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7162746/

Can post-exposure prophylaxis for COVID-19 be considered as one of outbreak response strategies in long-term care hospitals?

 

Because the exposed patients had to remain in multi-bed rooms receiving the care of similarly exposed careworkers and some of them might be in incubation periods, we concerned repetitive exposure episodes to newly developing patients. We started PEP with HCQ for patients and careworkers, on February 26 (Supplement Fig. 1). Physicians and pharmacists were educated about potential adverse events. HCQ was administrated orally at a dose of 400mg daily until the completion of 14 days of quarantine. A checklist for common adverse events was distributed (Supplement Fig. 2). The study was approved and informed consent was waived by the Institutional Review Board of Pusan National University Hospital (H-2003-014-089).

.....

It is usual that many patients are infected with COVID-19 in the setting of cluster outbreaks associated with LTCHs. In contrast, we had no additional confirmed cases among exposed patients and caregivers. However, it is not sure if PEP was effective because there was no control group. Both chloroquine and HCQ had antiviral activity against SARS-CoV-2 in vitro [3], [4], [5], [6]. Clinical data from China and France showed chloroquine was superior to the control treatment, leading to recommend chloroquine in patients with mild to severe COVID-19 pneumonia [7], [8], [9], [10].

 

......

In this study, HCQ was associated with mild adverse events. One patient having skin rash needed steroid for control without discontinuation. PEP was discontinued in 5 patients due to gastrointestinal upset, bradycardia, and for fasting.

 

......

 

There is a doctor in NY (Dr. Zelinco) and another doctor in LA who also say that this medicine (HCQ with ZINC and Azithromycin) works if given early based on their experience with patients.  You can easily search and read about that.

 

So, that White House doctor would give Trump as prophylactic HCQ+Zinc because he came in contact with Covid+ is in line with both S.Korea and Indian approaches. NYU grossman study also supports this use.

 

This is not a medical advise. Only for discussion. Please consult your doctor. These are prescription drugs not intended for self administration

[Liberty]

https://www.wsj.com/articles/wuhan-tests-nine-million-people-for-coronavirus-in-10-days-11590408910

[RadMan24]

https://www.researchsquare.com/article/rs-27223/v1

 

"Hydroxychloroquine in the treatment and prophylaxis of SARS-CoV-2 infection in non-human primates"

 

Sounds like Trump considers himself eligible for the study and participates voluntary.

Trump probably isn't even really taking Hydroxychloroquine.

 

He and others in the chain of command and military have probably been secretly receiving prophylactic treatments of plasma for months.

 

It's a great explanation for why he has been his normal self and has shown no signs of his supposedly legendary Germaphobia.

 

If you've forgotten, supposedly he couldn't have stumpfed the Russian prostitutes at the pee palace because he's so Germaphobic it would have been out of character. I'm left to conclude that either there are pee tapes out there or he's been getting convalescent plasma for months.

 

This is also a good explanation for why we did those repatriation flights to military bases and got people to volunteer for military-led "research". Also, not a bad explanation why we allowed for cruise ships to become Petri dishes. You've got to get the plasma from somewhere and you probably want to get it early and from a verifiable source. Importation from Wuhan is a great technique for that.

 

If anything the HCQ (Optionally with Zinc) will work earlier its given.

 

Viruses are not living things.  So they cannot be killed.  Read about late diagnosis HIV.

 

So we can only stop replication of viruses - hence if they work, they should work better earlier they are given.

 

https://www.ny1.com/nyc/all-boroughs/news/2020/05/12/nyu-study-looks-at-hydroxychloroquine-zinc-azithromycin-combo-on-decreasing-covid-19-deaths

 

NEW YORK - Researchers at NYU's Grossman School of Medicine found patients given the antimalarial drug hydroxychloroquine along with zinc sulphate and the antibiotic azithromycin were 44 percent less likely to die from the coronavirus.

 

Trump took HCQ+Zinc.  In above study they said it did not work in ICU but worked before ICU.  That is it worked before the virus multiplied in the body extensively.

 

So, one would expect it to work at the earliest stage - prophylactic.  Trump had come in contact with Covid positives.  So, his doctors gave him the medicine.  It is a prescription medicine.

 

The Indian govt has recently expanded its use

https://www.msn.com/en-in/news/other/govt-expands-hydroxychloroquine-as-prophylactic-for-asymptomatic-health-workers-fighting-covid-19/ar-BB14u2ZN

Govt expands Hydroxychloroquine as prophylactic for asymptomatic health workers fighting COVID-19

 

https://theprint.in/health/hcq-breakthrough-icmr-finds-its-effective-in-preventing-coronavirus-expands-its-use/427583/

HCQ breakthrough: ICMR finds it’s effective in preventing coronavirus, expands its use

 

They are reporting further clinical studies of this prophylactic use and results are expected in July.

 

S. Korea also they used it as prophylactic and even though its not a randomized double blind study, again there were encouraging results

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7162746/

Can post-exposure prophylaxis for COVID-19 be considered as one of outbreak response strategies in long-term care hospitals?

 

Because the exposed patients had to remain in multi-bed rooms receiving the care of similarly exposed careworkers and some of them might be in incubation periods, we concerned repetitive exposure episodes to newly developing patients. We started PEP with HCQ for patients and careworkers, on February 26 (Supplement Fig. 1). Physicians and pharmacists were educated about potential adverse events. HCQ was administrated orally at a dose of 400mg daily until the completion of 14 days of quarantine. A checklist for common adverse events was distributed (Supplement Fig. 2). The study was approved and informed consent was waived by the Institutional Review Board of Pusan National University Hospital (H-2003-014-089).

.....

It is usual that many patients are infected with COVID-19 in the setting of cluster outbreaks associated with LTCHs. In contrast, we had no additional confirmed cases among exposed patients and caregivers. However, it is not sure if PEP was effective because there was no control group. Both chloroquine and HCQ had antiviral activity against SARS-CoV-2 in vitro [3], [4], [5], [6]. Clinical data from China and France showed chloroquine was superior to the control treatment, leading to recommend chloroquine in patients with mild to severe COVID-19 pneumonia [7], [8], [9], [10].

 

......

In this study, HCQ was associated with mild adverse events. One patient having skin rash needed steroid for control without discontinuation. PEP was discontinued in 5 patients due to gastrointestinal upset, bradycardia, and for fasting.

 

......

 

There is a doctor in NY (Dr. Zelinco) and another doctor in LA who also say that this medicine (HCQ with ZINC and Azithromycin) works if given early based on their experience with patients.  You can easily search and read about that.

 

So, that White House doctor would give Trump as prophylactic HCQ+Zinc because he came in contact with Covid+ is in line with both S.Korea and Indian approaches. NYU grossman study also supports this use.

 

This is not a medical advise. Only for discussion. Please consult your doctor. These are prescription drugs not intended for self administration

 

On what basis are viruses not living things?

[Spekulatius]

 

On what basis are viruses not living things?

 

It can’t replicate by itself, it needs a host to replicate.

 

On a different matter, outbreak in Church in Germany - 107 cases all at once! Ouch. All churches in the area have been closed again.

https://www.spiegel.de/panorama/coronavirus-in-frankfurt-am-main-mehr-als-hundert-glaeubige-in-kirche-infiziert-a-a94cf16c-f765-4549-b49f-704f33568b00

 

(There is an escalation Rule in place that allows only 50 cases within 7 days /100k population that if exceeded lights to a re-tightening of distancing rules in the affected county area. This rule was triggered here in even more than one county)

 

[Liberty]

 

The bottom line analysis from the Korean CDC demonstrating that those testing positive for SARSCoV2 after recovering from covid WERE NOT infected or contagious. The positive hit on the subsequent PCR test was dead virus and could not replicate in viral cell culture.

[Pauly]

 

 

On what basis are viruses not living things?

 

Interesting reading on the subject : https://www.scientificamerican.com/article/are-viruses-alive-2004/

[rb]

 

On what basis are viruses not living things?

 

It can’t replicate by itself, it needs a host to replicate.

 

Doesn't a human, or any mammal for that matter need the same thing?

[Spekulatius]

 

On what basis are viruses not living things?

 

It can’t replicate by itself, it needs a host to replicate.

 

On a different matter, outbreak in Church in Germany - 107 cases all at once! Ouch. All churches in the area have been closed again.

https://www.spiegel.de/panorama/coronavirus-in-frankfurt-am-main-mehr-als-hundert-glaeubige-in-kirche-infiziert-a-a94cf16c-f765-4549-b49f-704f33568b00

 

(There is an escalation Rule in place that allows only 50 cases within 7 days /100k population that if exceeded lights to a re-tightening of distancing rules in the affected county area. This rule was triggered here in even more than one county)

In another article it was mentioned that one of the main reason why mean processing plant workers are so susceptible to COVID-19 is because they are operating in relative crowded conditions, but also because the air temperature is typically low (4-7 Deg C)  making the folks that stand there a long  time more susceptible to respiratory infections. Dalal  mentioned this - it applies to common cold, but COVID-19 likely as well.

 

This might be one reason why southern states do relatively better but it also might mean a second wave isomorphic likely in fall/ early winter just like the Flu.

[Spekulatius]

Here is another interesting paper. It’s basically showing evidence that COVID-19 progresses from an respiratory to a cardio  disease in its severe case. this manifests itself in blood vessel inflammation and clogging up small blood vessels causing oxygen deprivation. Ventilators don’t help much in this case any more this is a cardiovascular diseases at this point sind I know docs are treating this differently now (blood Thinners like Heparin etc.). Hopefully this will lead to better outcomes.

https://www.nejm.org/doi/full/10.1056/NEJMoa2015432

 

Now back to bashing Trump.

[DocSnowball]

Here is another interesting paper. It’s basically showing evidence that COVID-19 progresses from an respiratory to a cardio  disease in its severe case. this manifests itself in blood vessel inflation and clogging up small Blut vessels causing oxygen deprivation. Ventilators don’t help much in this case any more this is a cardiovascular diseases at this point sind I know docs are treating this differently now (blood Thinners like Heparin etc.). hopefully this will lead to better outcomes.

https://www.nejm.org/doi/full/10.1056/NEJMoa2015432

 

Now back to bashing Trump.

Excellent point. This is one of the things changing the mortality rate, along with having more hospital space and staff capacity available, and to some extent Remdesivir and IL-6 receptor blockers. It will be interesting to look at the mortality rate by severity category June onwards now that so much more is known.

[Liberty]

Interesting vaccine context vs SARS-Cov1, MERS, etc

 

[Investor20]

https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/009768s037s045s047lbl.pdf

 

Hydroxychloroquine dosage recommendations by FDA approved label:

 

Rheumatoid Arthritis

 

The action of hydroxychloroquine is cumulative and may require weeks to months to achieve the maximum therapeutic effect (see CLINICAL PHARMACOLOGY).

 

Initial adult dosage: 400 mg to 600 mg (310 to 465 mg base) daily, administered as a single daily dose or in two divided doses. In a small percentage of patients, side effects may require temporary reduction of the initial dosage.

 

Maintenance adult dosage: When a good response is obtained, the dosage may be reduced by 50 percent and continued at a maintenance level of 200 mg to 400 mg (155 to 310 mg base) daily, administered as a single daily dose or in two divided doses. Do not exceed 600 mg or 6.5 mg/kg (5 mg/kg base) per day, whichever is lower, as the incidence of retinopathy has been reported to be higher when this maintenance dose is exceeded. Corticosteroids and salicylates may be used in conjunction with PLAQUENIL, and they can generally be decreased gradually in dosage or eliminated after a maintenance dose of PLAQUENIL has been achieved.

 

Lupus Erythematosus

 

The recommended adult dosage is 200 to 400 mg (155 to 310 mg base) daily, administered as a single daily dose or in two divided doses.  Doses above 400 mg a day are not recommended.   The incidence of retinopathy has been reported to be higher when this maintenance dose is exceeded.

 

John Hopkins article on Lupus treatment:

 

Lastly, remember that even though you may feel the benefits of anti-malarial therapy after about a month of treatment, it may take up to three months for the full benefits of the drug to manifest. If you experience any serious adverse effects, notify your doctor.

Can I stop taking anti-malarials suddenly?

 

Long-term anti-malarial use is normally safe. However, if you stop taking your anti-malarial drugs, you may experience a lupus flare.

https://www.hopkinslupus.org/lupus-treatment/lupus-medications/antimalarial-drugs/

 

NYU Grossman study dose:

 

Patients were categorized  based on their exposure to hydroxychloroquine (400 mg load followed by 200 mg twice daily for five days) and azithromycin (500 mg once daily) alone or with zinc sulfate (220 mg capsule containing 50 mg elemental zinc twice daily for five days) as treatment in addition to standard supportive care.

https://www.medrxiv.org/content/10.1101/2020.05.02.20080036v1.full.pdf

 

Please explain the problem.

 

For discussion only. Not medical advise. Please consult your doctor.  These are prescription only medicines.

[Cigarbutt]

On what basis are viruses not living things?

It can’t replicate by itself, it needs a host to replicate.

On a different matter, outbreak in Church in Germany - 107 cases all at once! Ouch. All churches in the area have been closed again.

https://www.spiegel.de/panorama/coronavirus-in-frankfurt-am-main-mehr-als-hundert-glaeubige-in-kirche-infiziert-a-a94cf16c-f765-4549-b49f-704f33568b00

(There is an escalation Rule in place that allows only 50 cases within 7 days /100k population that if exceeded lights to a re-tightening of distancing rules in the affected county area. This rule was triggered here in even more than one county)

In another article it was mentioned that one of the main reason why meat processing plant workers are so susceptible to COVID-19 is because they are operating in relative crowded conditions, but also because the air temperature is typically low (4-7 Deg C)  making the folks that stand there a long  time more susceptible to respiratory infections. Dalal  mentioned this - it applies to common cold, but COVID-19 likely as well.

This might be one reason why southern states do relatively better but it also might mean a second wave isomorphic likely in fall/ early winter just like the Flu.

i've looked at various meat processors over the years (for example Hormel Foods, HRL) and they have produced impressive financial numbers IMO related to impressive growth in productivity but also (ab)use of an expendable workforce. In Germany, it seems that a majority of meat processing workers are migrants (Eastern and Southern Europe). In the US, it's been reported that 30 to 50% of the workforce is composed of undocumented immigrants. It appears that living conditions for the typical worker involves crowded and multi-generational habitats. It looks like some places are taking advantage of the fact that a virus does not replicate well in robots (even those that don't take chloroquine, zinc, vitamin F3 and elderberry extract juice).

https://www.wired.com/story/covid-19-makes-the-case-for-more-meatpacking-robots/

 

Anecdotal addition:

As a kid, i had the opportunity to visit a sausage factory. i came away fascinated by human ingenuity. It also took a while before i could eat sausages. Often, it's better not to know. At times, it is.