Biggest regrets of the older posters here?

[rogermunibond]

I’m totally pro exercise.  But I’m anti linking mouse model papers to talk up the effects of exercise.  
 

here are two good ones in HUMANS - increase in life expectancy and improved cancer survival rates. 
 

there’s a typo in the tweet. Adds 6.3 years in life expectancy 

 

Edited November 15 by rogermunibond

[boilermaker75]

On 11/14/2024 at 10:29 AM, rogermunibond said:

 

Sorry but there's a lot of junk science and unreplicated studies which purport to show benefits for x y and z.  The exercise hipposcampus study is in mice.

 

 

 

MRI studies have found fit children have hippocampi about 12% larger than unfit children.

 

In his book Boost Your Brain, Johns Hopkins neurologist Majid Totuhi, M.D., Ph.D. shows MRI scans with 16% increases in the size of the hippocampus after a vigorous exercise regimen. 

 

Arthur Kramer’s lab at U of I also found measurable increases in gray and white matter after 6 months of exercise in older adults. (S. J. Colcombe, K. I. Erickson, P. E. Scalf, J. S. Kim, R. Prakash, E. McAuley, S. Elavsky, D. X. Marquez, L. Hu and A. F. Kramer, "Aerobic Exercise Training Increases Brain Volume in Aging Humans," The Journals of Gerontology; Series A, vol. 61, no. 11, pp. 1166-1170, 2006).

Besides exercise, you can increase brain regions with study (Maguire, E. A.; Gadian, D. G.; Johnsrude, I. S.; Good, C. D.; Ashburner, J.; Frackowiak, R. S. J.; Frith, C. D., “Navigation-related structural change in the hippocampi of taxi Drivers,” Proceedings of the National Academy of Sciences. 97 (8): 4398–4403 (2000) and Katherine Woodlett and Eleanor Maguire, “Acquiring "the Knowledge" of London’s Layout Drives Structural Brain Changes,” Current Biology 21, 2109-2114 (2011).) and meditation (Britta K. Hölzel, James Carmody, Mark Vangel, Christina Congleton, Sita M. Yerramsetti, Tim Gard, and Sara W. Lazar, “Mindfulness Practice Leads to Increases in Regional Brain Gray Matter Density,” Psychiatry Research: Neuroimaging 191, no. 1 (2011): 36–43)

 

 

[boilermaker75]

On 11/14/2024 at 12:07 PM, cubsfan said:

Not sure what the controversy is here. Excercise in the proper doses does much to turn back the clock and lessen the impacts of aging. You CAN feel young again - but it takes consistency and work. 

 

Just ask the old guys like me & @boilermaker75 !

 

We are living proof you can prevent sarcopenia!

 

[boilermaker75]

On 11/13/2024 at 12:19 PM, nsx5200 said:

https://news.mit.edu/2024/when-muscles-work-out-they-help-neurons-grow-1112

"Now, MIT engineers have found that exercise can also have benefits at the level of individual neurons. They observed that when muscles contract during exercise, they release a soup of biochemical signals called myokines. In the presence of these muscle-generated signals, neurons grew four times farther compared to neurons that were not exposed to myokines. These cellular-level experiments suggest that exercise can have a significant biochemical effect on nerve growth."

 

I guess this also serve as a reminder to keep up with your exercise routine, or if you don't have one, start one.

 

It is known these myokines can cross the blood-brain barrier and promote neuroplasticity and blood vessel growth. Neurologist refer to brain-derived neurotropic factor (BDNF) as brain fertilizer. Yes 75% of the BDNF in your brain is created there, hence the name, but it is also released from your muscles during exercise.

 

Last week I talked about exercise in my class, "Keys to Learning."

Edited November 16 by boilermaker75

[james22]

The tragedy of old age is not that one is old, but that one is young. Oscar Wilde

[dpetrescu]

One regret (but not really) - is not using the lessons from value investing earlier in life.

 

Imagine a life where very early you “invest” long term on your best 5 ideas in life - relationship, music, design, learning, health, etc. And you go all in. Every day you “invest” with your limited time and effort - to gain 7% improvement in those goals every year. Compound that return over a few decades and a person could reach wonderful heights in life.

 

Like investing - the biggest challenge is finding the punchcard things that you can invest in for life that will generate for you specifically the most happiness and/or reward. Also like investing you can just chose life “index funds”, the human basics like health, nutrition, relationships, learning, etc. and maybe later you can add synthesizers, piano, Ableton

[RichardGibbons]

It's not that clear to me that many things compound in life. Actual exponential growth in real life is pretty rare, I think, because it doesn't take much exponential growth before things break.

[bizaro86]

1 hour ago, RichardGibbons said:

It's not that clear to me that many things compound in life. Actual exponential growth in real life is pretty rare, I think, because it doesn't take much exponential growth before things break.

 

And there are other factors working against progress in many fields.

 

As an example - I love baseball, and go to the batting cage every week. I enjoy it and it's good exercise. But I'm not a 7% better hitter than I was last year. In fact I'm probably worse because of age related decay in reaction times etc. 

 

So many fields are like that, or at the very least have diminishing returns. The first 100 hours of practice makes you good, the first 1000 great. But it might take 10,000 to become elite. So effort is going uo exponentially but skill only linearly.